Botox® for Depression
in conjunction with conventional therapy
At Horizon Behavioral Health, we are committed to offering innovative, evidence-based treatments to help our patients achieve lasting relief from mood disorders. One emerging option is the use of Botox® (onabotulinumtoxinA) as an adjunctive treatment for depression.
Early clinical research shows that roughly 50% of patients experience improvement in depressive symptoms after receiving targeted Botox injections, with some individuals also reporting reduced anxiety. Studies indicate that benefits often begin to appear within several weeks and can continue for several months following treatment. This approach is not performed for cosmetic purposes, though cosmetic changes may occur. Its primary goal is to support emotional regulation by reducing facial patterns associated with negative mood states.
How Botox® for Depression Works
Originally developed for medical and cosmetic uses, Botox has also been shown in multiple clinical studies to help improve symptoms of depression—particularly when injected into the small “frown” muscles between the eyebrows (the “glabellar” area). This is thought to work by interrupting the facial expressions that reinforce negative emotions, as well as by influencing brain regions involved in mood regulation.
- Fast: 15–20 min procedure
- Onset: 2–4 weeks; peak at 6 weeks
- Duration: 2–3 months
- Low side effects: Any side effects are mild and short-lived
What To Expect
- A series of tiny injections in the glabellar area, completed in just a few minutes.
- Most patients begin to notice improvement within 2–4 weeks, with peak effects at about 6 weeks.
- Benefits typically last 2–3 months, after which treatment can be repeated.
Why consider Botox?
- Low systemic side effects – does not affect the rest of the body like many oral medications.
- Quick procedure with no downtime.
- Can be safely combined with therapy, medication, TMS, and Spravato®.
Additional Reading
If you are interested in learning more about the emerging research behind Botox for depression, the following articles and studies offer helpful background and clinical context:
Important to know
Botox for depression is considered an off-label use, meaning it is not FDA-approved for this specific purpose. We follow strict screening, informed consent, and outcome tracking to ensure patient safety and effectiveness. Botox for depression is not covered by insurance.
If you are living with depression that has not fully improved with traditional treatments, you may be a candidate for this innovative approach.
Interested in Learning More?
If you are curious whether Botox for depression may be a helpful addition to your treatment plan, our team is available to guide you through the process and answer any questions you may have. We can explain how the treatment works, discuss expected timelines, and help determine whether this approach aligns with your goals. Contact us to learn more or to schedule an appointment.
